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The Mouse Renal Tract Malformations Gene Database (MoRTalGene) is the first resource that provides renal development association predictions for all mouse genes. The predictions generated in this project, based on large numbers of gene features, are obtained through a machine learning classification tool.
 
Trulli
Diagram of normal and abnormal kidney development (based on Kerecuk, Schreuder and Woolf, 2008)
Trulli
In the kidney from the affected fetus, glomeruli are cystic, with dilated Bowman’s spaces (asterisks), a characteristic of fetal urinary flow obstruction (Houweling et al, 2019)
 
Search Genes by ID
  • Enter a list of gene identifiers one per line
    • An example for searching genes by Gene Name - Cdc45
    • An example for searching genes by Ensembl ID - ENSMUSG00000000028
    • An example for searching genes by MGI ID - MGI:1338073
    • An example for searching genes by UniProt ID - Q9Z1X9

  • Search results can be downladed as a CSV file from the "Download File" link

Search for Genes
  • Searching for known and predicted kidney and nonkidney genes
  • Known kidney and nonkidney genes were used as training datasets in model development
  • Search results can be downladed as a CSV file from the "Download File" link
Known Kidney Genes
Predicted Kidney Genes
All Kidney Genes (Known and Predicted)
Known Nonkidney Genes
Predicted Nonkidney Genes
All Nonkidney Genes (Known and Predicted)
Predicted Genes
All Genes

Search with Phenotype Terms Associated with Renal Development
  • All Mammalian Phenotype (MP) terms in MGI associated with genes causing renal tract malformations
  • These MP terms were used to retrieve known kidney genes from MGI


Search for Genes and their Kidney Status by Mouse Chromosome
  • Searching for genes located on a Chromosome
  • We used the Ensembl release 93 dataset of mouse genes (GRCm38.p6)
    to annotate gene locations


Kidney Genes Nonkidney Genes All Genes

Region Start (bp)
Region End (bp)



Kids Kidney Research has now become a part of Kidney Research UK.